The Roast Beef and Cheddar Sandwich with Horseradish Sauce is a bold, satisfying classic that brings together tender beef, sharp cheddar cheese, and a creamy, zesty horseradish sauce. This sandwich is inspired by traditional American deli favorites, where simple, high-quality ingredients are layered to create big flavor with minimal fuss.
Perfect for lunch, casual dinners, or game-day meals, this sandwich strikes the ideal balance between hearty and indulgent. Whether served warm with melted cheese or cold for a quick bite, it’s a timeless recipe that never disappoints.
I love this recipe because it delivers rich, deli-style flavor in a simple homemade sandwich.
The combination of savory roast beef, sharp cheddar, and spicy horseradish sauce creates a bold taste that’s comforting and satisfying. It’s quick to prepare but feels filling and special every time.
Preparation Time: 10 minutes
Cooking Time: 5–8 minutes (optional, for toasting/melting)
Total Time: 15 minutes
Servings: 2 sandwiches
Calories: Approximately 520 calories per serving
Course: Lunch / Main Dish
Cuisine: American
Step 1: Make the Horseradish Sauce
In a small bowl, mix mayonnaise, prepared horseradish, Dijon mustard (if using), salt, and pepper until smooth. Adjust horseradish to desired heat level.
Step 2: Prepare the Bread
Slice the rolls or bread in half. Lightly butter or brush with olive oil if you plan to toast.
Step 3: Assemble the Sandwich
Layer sliced roast beef evenly on the bottom half of the bread. Top with cheddar cheese slices.
Step 4: Warm the Sandwich (Optional)
Place the sandwich under a broiler or in a skillet until the cheese melts and the bread is lightly toasted.
Step 5: Add Sauce and Finish
Spread horseradish sauce on the top half of the bread. Add optional toppings if desired, close the sandwich, and serve.

Serve the Roast Beef and Cheddar Sandwich warm with the cheese melted for maximum comfort. Pair with fries, potato chips, coleslaw, or a simple green salad. It’s also great with pickles or a cup of soup on the side.
Spicy Version: Add extra horseradish or a dash of hot sauce.
Onion Lover’s: Add caramelized or crispy fried onions.
Swiss Swap: Replace cheddar with Swiss cheese.
Low-Carb Option: Serve open-faced or in lettuce wraps.
Au Jus Style: Serve with warm beef broth for dipping.
Storage:
Store leftover roast beef and horseradish sauce separately in airtight containers in the refrigerator for up to 3 days.
Freezing:
Freezing assembled sandwiches is not recommended. Roast beef alone can be frozen for up to 2 months.
The Roast Beef and Cheddar Sandwich with Horseradish Sauce is a hearty, flavor-packed classic that’s easy to make and incredibly satisfying. With tender beef, sharp cheese, and a creamy kick of horseradish, this sandwich delivers comfort and bold taste in every bite. Whether for a quick lunch or a casual dinner, it’s a must-have recipe you’ll return to again and again.
The Roast Beef and Cheddar Sandwich with Horseradish Sauce is a bold, satisfying classic that brings together tender beef, sharp cheddar cheese, and a creamy, zesty horseradish sauce. This sandwich is inspired by traditional American deli favorites, where simple, high-quality ingredients are layered to create big flavor with minimal fuss.